A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, Indications 1.For the short-term management of anxiety, 2.Treatment of Panic disorder. Contra-indications of Alprazolam 1.Hypersensitivity to Benzodiazepines 2.Acute angle closure glaucoma Mechanism of Action of Alprazolam Alprazolam mainly acts on Limbic system and ascending reticular formation in the CNS and binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will produce an increase in the concentration of the inhibitory neurotransmitter GABA and increase in chloride ions and decreases firing rate of neuron. This in turn alters normal functions of the body.